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M9480154.TXT
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1994-08-09
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Document 0154
DOCN M9480154
TI Long-term dietary vitamin E retards development of retrovirus-induced
disregulation in cytokine production.
DT 9410
AU Wang Y; Huang DS; Eskelson CD; Watson RR; Department of Family and
Community Medicine, University of; Arizona, Tucson 85724.
SO Clin Immunol Immunopathol. 1994 Jul;72(1):70-5. Unique Identifier :
AIDSLINE MED/94291303
AB A 15-fold increase in dietary vitamin E (160 IU/liter) normalized
hepatic and serum levels of vitamin E normally reduced by retrovirus
infection. It also significantly retarded development of splenomegaly
and hypergammaglobulinemia induced by retrovirus infection, while
significantly restoring release of interleukin-2 (IL) and
interferon-gamma by splenocytes which are suppressed by retrovirus
infection. Retrovirus infection elevated production of IL-4 and IL-6 by
splenocytes, but this elevation was inhibited by vitamin E. Increased
levels of IL-6 and tumor necrosis factor-alpha produced by splenocytes
during progression to murine AIDS were also inhibited by vitamin E.
Vitamin E supplementation also helped restore retrovirus-suppressed
splenocyte proliferation. These data indicate that vitamin E
supplementation can help overcome retrovirus-induced reduction in tissue
vitamin E, modulate cytokine release, and normalize immune dysfunctions
during progression to murine AIDS.
DE Animal Antibodies, Monoclonal Cell Division/DRUG EFFECTS
Cytokines/*BIOSYNTHESIS/*IMMUNOLOGY Diet Enzyme-Linked Immunosorbent
Assay Female Hypergammaglobulinemia/MICROBIOLOGY/THERAPY Mice Mice,
Inbred C57BL Murine Acquired Immunodeficiency
Syndrome/*IMMUNOLOGY/*THERAPY Spleen/CYTOLOGY
Splenomegaly/MICROBIOLOGY/THERAPY Support, U.S. Gov't, P.H.S.
T-Lymphocytes, Helper-Inducer/IMMUNOLOGY Vitamin E/*PHARMACOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).